rd10 mice Search Results


90
GemPharmatech Co Ltd pigmented rd10 mice
Pigmented Rd10 Mice, supplied by GemPharmatech Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rd10+mice/pm37582961-180-1-10?v=GemPharmatech+Co+Ltd
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86
Jackson Laboratory rd10 mice
FIGURE 1 Photoreceptor morphology in wild-type (WT) mouse and <t>rd10</t> mouse retinas. A, DAPI-Staining of the vertical section of P46 WT mouse retina. There were 12-15 layers of soma of photoreceptors in the outer nuclear layer (ONL). B, Only 1-2 layers of soma of photoreceptors observed in P46 rd10 mouse retina. C, The morphology of cone outer segments/inner segments labeled by red/green opsin in P46 WT mouse retina appeared normal. D, The morphology of cone outer segments/inner segments in P46 rd10 mouse retina was disrupted. Opsin labeling showed cones lost their morphology and indicated cells death. Scale bar = 20 µm in A and B; 10 µm in C and D
Rd10 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rd10+mice/10__1096_slash_fj__202001315rr-25-0-6?v=Jackson+Laboratory
Average 86 stars, based on 1 article reviews
rd10 mice - by Bioz Stars, 2026-08
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90
Johns Hopkins HealthCare rd10 mice
FIGURE 1 Photoreceptor morphology in wild-type (WT) mouse and <t>rd10</t> mouse retinas. A, DAPI-Staining of the vertical section of P46 WT mouse retina. There were 12-15 layers of soma of photoreceptors in the outer nuclear layer (ONL). B, Only 1-2 layers of soma of photoreceptors observed in P46 rd10 mouse retina. C, The morphology of cone outer segments/inner segments labeled by red/green opsin in P46 WT mouse retina appeared normal. D, The morphology of cone outer segments/inner segments in P46 rd10 mouse retina was disrupted. Opsin labeling showed cones lost their morphology and indicated cells death. Scale bar = 20 µm in A and B; 10 µm in C and D
Rd10 Mice, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rd10+mice/pm36736930-19-4-24?v=Johns+Hopkins+HealthCare
Average 90 stars, based on 1 article reviews
rd10 mice - by Bioz Stars, 2026-08
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86
Inserm Transfert rd10 mice
FIGURE 1 Photoreceptor morphology in wild-type (WT) mouse and <t>rd10</t> mouse retinas. A, DAPI-Staining of the vertical section of P46 WT mouse retina. There were 12-15 layers of soma of photoreceptors in the outer nuclear layer (ONL). B, Only 1-2 layers of soma of photoreceptors observed in P46 rd10 mouse retina. C, The morphology of cone outer segments/inner segments labeled by red/green opsin in P46 WT mouse retina appeared normal. D, The morphology of cone outer segments/inner segments in P46 rd10 mouse retina was disrupted. Opsin labeling showed cones lost their morphology and indicated cells death. Scale bar = 20 µm in A and B; 10 µm in C and D
Rd10 Mice, supplied by Inserm Transfert, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rd10+mice/pm41610519-334-13-9?v=Inserm+Transfert
Average 86 stars, based on 1 article reviews
rd10 mice - by Bioz Stars, 2026-08
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Image Search Results


FIGURE 1 Photoreceptor morphology in wild-type (WT) mouse and rd10 mouse retinas. A, DAPI-Staining of the vertical section of P46 WT mouse retina. There were 12-15 layers of soma of photoreceptors in the outer nuclear layer (ONL). B, Only 1-2 layers of soma of photoreceptors observed in P46 rd10 mouse retina. C, The morphology of cone outer segments/inner segments labeled by red/green opsin in P46 WT mouse retina appeared normal. D, The morphology of cone outer segments/inner segments in P46 rd10 mouse retina was disrupted. Opsin labeling showed cones lost their morphology and indicated cells death. Scale bar = 20 µm in A and B; 10 µm in C and D

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 1 Photoreceptor morphology in wild-type (WT) mouse and rd10 mouse retinas. A, DAPI-Staining of the vertical section of P46 WT mouse retina. There were 12-15 layers of soma of photoreceptors in the outer nuclear layer (ONL). B, Only 1-2 layers of soma of photoreceptors observed in P46 rd10 mouse retina. C, The morphology of cone outer segments/inner segments labeled by red/green opsin in P46 WT mouse retina appeared normal. D, The morphology of cone outer segments/inner segments in P46 rd10 mouse retina was disrupted. Opsin labeling showed cones lost their morphology and indicated cells death. Scale bar = 20 µm in A and B; 10 µm in C and D

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Staining, Labeling

FIGURE 2 Alpha RGCs in P46 rd10 and WT mouse retinas. A, ON, OFF alpha RGC, and ON-OFF RGC of P46 rd10 mouse retina showed no visible morphological damage compared to the same types of RGCs in WT mouse retinas with Neurobiotin injection. Lower images showed cells double labeled with anti-ChAT antibody (blue). Scale bar = 20 µm. B, Stratification of ON, OFF alpha RGC, and ON-OFF RGCs in rd10 and WT mouse. IPL depth is normalized with 0 and 1 correspond to the ON and OFF ChAT bands, respectively (dashed lines). Bar means density ± SEM. C and D, Dendritic field equivalent diameter and somata size of ON, OFF alpha RGC, and ON-OFF RGC had no statistical difference between rd10 mice retinas and WT mice retinas

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 2 Alpha RGCs in P46 rd10 and WT mouse retinas. A, ON, OFF alpha RGC, and ON-OFF RGC of P46 rd10 mouse retina showed no visible morphological damage compared to the same types of RGCs in WT mouse retinas with Neurobiotin injection. Lower images showed cells double labeled with anti-ChAT antibody (blue). Scale bar = 20 µm. B, Stratification of ON, OFF alpha RGC, and ON-OFF RGCs in rd10 and WT mouse. IPL depth is normalized with 0 and 1 correspond to the ON and OFF ChAT bands, respectively (dashed lines). Bar means density ± SEM. C and D, Dendritic field equivalent diameter and somata size of ON, OFF alpha RGC, and ON-OFF RGC had no statistical difference between rd10 mice retinas and WT mice retinas

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Injection, Labeling

FIGURE 3 RGCs have similar cell responses in P46 rd10 and WT mouse retina. Voltage-clamped of ON, OFF alpha RGCs, and ON-OFF RGCs from P46 rd10 mouse retina at holding voltage of −68 mV (blue) and 0 mV (red) to isolate excitatory and inhibitory postsynapticcurrents (EPSCs/IPSCs). A, ON alpha RGC of both rd10 and WT mouse had light response to light stimulus 1 second 525 nm light stimuli (light intensity = 108.53 Rh*/rod/sec). Application of 100 μM PTX decreased IPSCs (red) but increased EPSCs evoked by light. B, Application of PTX also decreased IPSCs (red) and increased EPSCs evoked by light on OFF alpha RGC of both rd10 and WT mice. C, Application of PTX decreased IPSCs of ON and OFF response, increased EPSCs of OFF response, not ON response of ON-OFF RGC in WT retina. PTX only decreased the IPSCs of ON response of ON-OFF RGC in rd10 retina. Asterisk indicated a statistically significant difference (P < .05). D, Normalized changes of EPSCs/IPSCss after PTX application between rd10 and WT retinas. RGCs had similar cell responses in P46 rd10 and WT mouse retinas

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 3 RGCs have similar cell responses in P46 rd10 and WT mouse retina. Voltage-clamped of ON, OFF alpha RGCs, and ON-OFF RGCs from P46 rd10 mouse retina at holding voltage of −68 mV (blue) and 0 mV (red) to isolate excitatory and inhibitory postsynapticcurrents (EPSCs/IPSCs). A, ON alpha RGC of both rd10 and WT mouse had light response to light stimulus 1 second 525 nm light stimuli (light intensity = 108.53 Rh*/rod/sec). Application of 100 μM PTX decreased IPSCs (red) but increased EPSCs evoked by light. B, Application of PTX also decreased IPSCs (red) and increased EPSCs evoked by light on OFF alpha RGC of both rd10 and WT mice. C, Application of PTX decreased IPSCs of ON and OFF response, increased EPSCs of OFF response, not ON response of ON-OFF RGC in WT retina. PTX only decreased the IPSCs of ON response of ON-OFF RGC in rd10 retina. Asterisk indicated a statistically significant difference (P < .05). D, Normalized changes of EPSCs/IPSCss after PTX application between rd10 and WT retinas. RGCs had similar cell responses in P46 rd10 and WT mouse retinas

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques:

FIGURE 4 PTX application induced light-evoked response of RGCs in P46 rd10 mouse retina. A-C, There was no light-evoked response of alpha-like RGCs in P46 rd10 mouse retina with increasing light stimulation (525 nm full-field light stimulus from 0 to 108.53 Rh*/rod/s, light stimulation time: 1 second). D-H, raster plots of an alpha-like RGC to the same full-field light stimulus of increasing intensity after application of picrotoxin (PTX). I-M, peristimulus time histogram of the alpha-like RGC to increasing light intensity stimulus. N, Intensity- response plot of the RGC with data points fitted by a Michaelis-Menten equation. The threshold sensitivity of this RGC (16 Rh*/rod/s) was calculated as 5% of the maximal response (spike frequency) and is indicated by the arrowhead below (red triangle). O, Spikes increased after PTX application. The error bar in the figure indicates SEM within each group. P, Q and R, S, As a control, there was no light-evoked response of alpha RGC in P56 rd10 mouse retina and after PTX application. (525 nm full-field light stimulus test at 13.69 and 108.53 Rh*/rod/s, light stimulation time: 1 second)

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 4 PTX application induced light-evoked response of RGCs in P46 rd10 mouse retina. A-C, There was no light-evoked response of alpha-like RGCs in P46 rd10 mouse retina with increasing light stimulation (525 nm full-field light stimulus from 0 to 108.53 Rh*/rod/s, light stimulation time: 1 second). D-H, raster plots of an alpha-like RGC to the same full-field light stimulus of increasing intensity after application of picrotoxin (PTX). I-M, peristimulus time histogram of the alpha-like RGC to increasing light intensity stimulus. N, Intensity- response plot of the RGC with data points fitted by a Michaelis-Menten equation. The threshold sensitivity of this RGC (16 Rh*/rod/s) was calculated as 5% of the maximal response (spike frequency) and is indicated by the arrowhead below (red triangle). O, Spikes increased after PTX application. The error bar in the figure indicates SEM within each group. P, Q and R, S, As a control, there was no light-evoked response of alpha RGC in P56 rd10 mouse retina and after PTX application. (525 nm full-field light stimulus test at 13.69 and 108.53 Rh*/rod/s, light stimulation time: 1 second)

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Control

FIGURE 5 Effects of selective GABA receptor blockers-on RGCs in P43 rd10 mouse retina. Effects of the GABA A-selective blocker- gabazine (SR-95531, 10 μm) and the GABA C-selective blocker-1,2,5,6-tetrahydropyridin-4-yl-methylphosphinic acid (TPMPA, 100 μm) were determined in a different sequence on the RGC in rd10 mouse retina. SR, not TPMPA had a significant effect on restoring the light response in rd10 mouse retina. A, C, (raster plots) and B, D, (peristimulus time histogram) data showed that RGC had no light-evoked response to 71.24 Rh*/rod/s in the rd10 mouse retina. E and F, showed the application of TPMPA alone did not affect the light-evoked response of the cell, but the subsequent application of SR induced the light-evoked response (I and J). Application of SR alone induced a light-evoked response in RGC (G and H). Later the application of TPMPA did not change the light-evoked response. M, Summary of spikes change from experiments A to L. Spikes mainly increased after the application of SR. N, Normalized responses after sequencing application SR and TPMPA. Application of SR had a significant effect of inducing the light-evoked response in the rd10 mouse retina. The data are presented as averages. Error bars are SEM. Significance is based on Student's t test, where *P < .05, not statistically (n.s.). Significant P > .05

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 5 Effects of selective GABA receptor blockers-on RGCs in P43 rd10 mouse retina. Effects of the GABA A-selective blocker- gabazine (SR-95531, 10 μm) and the GABA C-selective blocker-1,2,5,6-tetrahydropyridin-4-yl-methylphosphinic acid (TPMPA, 100 μm) were determined in a different sequence on the RGC in rd10 mouse retina. SR, not TPMPA had a significant effect on restoring the light response in rd10 mouse retina. A, C, (raster plots) and B, D, (peristimulus time histogram) data showed that RGC had no light-evoked response to 71.24 Rh*/rod/s in the rd10 mouse retina. E and F, showed the application of TPMPA alone did not affect the light-evoked response of the cell, but the subsequent application of SR induced the light-evoked response (I and J). Application of SR alone induced a light-evoked response in RGC (G and H). Later the application of TPMPA did not change the light-evoked response. M, Summary of spikes change from experiments A to L. Spikes mainly increased after the application of SR. N, Normalized responses after sequencing application SR and TPMPA. Application of SR had a significant effect of inducing the light-evoked response in the rd10 mouse retina. The data are presented as averages. Error bars are SEM. Significance is based on Student's t test, where *P < .05, not statistically (n.s.). Significant P > .05

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Sequencing

FIGURE 6 Effects of blocking selective glycine receptor on RGC light-evoked response in rd10 mouse retina. A, (raster plots) and B, (peristimulus time histogram) data showing that RGC had no light-evoked response to 71.24 Rh*/rod/s in rd10 mouse retina. Application of the glycine receptor antagonist-strychnine (1 μM) did not induce a light-evoked response (C and D). The red-line is 95% confidence line

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 6 Effects of blocking selective glycine receptor on RGC light-evoked response in rd10 mouse retina. A, (raster plots) and B, (peristimulus time histogram) data showing that RGC had no light-evoked response to 71.24 Rh*/rod/s in rd10 mouse retina. Application of the glycine receptor antagonist-strychnine (1 μM) did not induce a light-evoked response (C and D). The red-line is 95% confidence line

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Blocking Assay

FIGURE 7 Effects of blocking dopaminergic circuitry on the light-evoked response of RGCs in rd10 mouse retina. A, G, (raster plots) and B, H, (peristimulus time histogram) data showing that RGC had no light-evoked response to 71.24 Rh*/rod/s in rd10 mouse retina. Application of dopamine receptor 1 antagonist-SCH 23390 (5 μM) or dopamine receptor 2 antagonist-eticlopride (25 μM) alone did not induce the light-evoked response of RGC (C, D and I, J). However, the addition of 100 μM PTX induced a robust light-evoked response of the RGC in the rd10 mouse retina (E, F and K, L). M, Spikes increased only after the application of PTX. The error bar in the figure indicates SEM within each group

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 7 Effects of blocking dopaminergic circuitry on the light-evoked response of RGCs in rd10 mouse retina. A, G, (raster plots) and B, H, (peristimulus time histogram) data showing that RGC had no light-evoked response to 71.24 Rh*/rod/s in rd10 mouse retina. Application of dopamine receptor 1 antagonist-SCH 23390 (5 μM) or dopamine receptor 2 antagonist-eticlopride (25 μM) alone did not induce the light-evoked response of RGC (C, D and I, J). However, the addition of 100 μM PTX induced a robust light-evoked response of the RGC in the rd10 mouse retina (E, F and K, L). M, Spikes increased only after the application of PTX. The error bar in the figure indicates SEM within each group

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Blocking Assay

FIGURE 8 PTX induced STR and increased the amplitude of ERG b-wave, but not the amplitude of a-wave in P41 rd10 mouse retina. In P41 rd10 mouse, no positive or negative scotopic threshold response (pSTR/nSTR) could be observed. pSTR appeared at around 100 ms following PTX application (A). PBS application as vehicle control. Figure B showed representative wave traces recorded from the P41 rd10 mouse and PTX application. PBS was applied as a control. Compared with WT mice, rd10 mice had significantly lower b-wave amplitudes in the scotopic range (P < .05) (C and D, D is an enlarged image of C). Application of PTX significantly increased b-wave amplitudes (P < .05) in rd10 mouse retina (D). However, PTX application did not increase the amplitude of ERG a-wave at almost all intensities (P > .05, except 0.3 cd*s/m2, P < .05) (E and F, F is enlarged image of E). Polynomial fitting was applied from Figure C to F. Error bar in the figure indicates SEM within each group. Significance is based on the Student's t test, where *P < .05

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 8 PTX induced STR and increased the amplitude of ERG b-wave, but not the amplitude of a-wave in P41 rd10 mouse retina. In P41 rd10 mouse, no positive or negative scotopic threshold response (pSTR/nSTR) could be observed. pSTR appeared at around 100 ms following PTX application (A). PBS application as vehicle control. Figure B showed representative wave traces recorded from the P41 rd10 mouse and PTX application. PBS was applied as a control. Compared with WT mice, rd10 mice had significantly lower b-wave amplitudes in the scotopic range (P < .05) (C and D, D is an enlarged image of C). Application of PTX significantly increased b-wave amplitudes (P < .05) in rd10 mouse retina (D). However, PTX application did not increase the amplitude of ERG a-wave at almost all intensities (P > .05, except 0.3 cd*s/m2, P < .05) (E and F, F is enlarged image of E). Polynomial fitting was applied from Figure C to F. Error bar in the figure indicates SEM within each group. Significance is based on the Student's t test, where *P < .05

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Control

FIGURE 9 Application of PTX leads to improve in behavioral measures of spatial vision in rd10 mouse eyes. Photopic optomotor responses from P41 eyes of rd10 with the application of PTX significantly(P < .05)increased both visual acuity (A, spatial frequency) tested at 100% contrast and contrast sensitivity (B, tested at 0.092 cycle/degree) with 1.5-Hz temporal frequency. PBS loaded as vehicle control had no statistic difference to the rd10 untreated group. For all panels, data are presented as mean ± SEM, significance is based on unpaired Student's t test, where *P < .05

Journal: The FASEB Journal

Article Title: Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

doi: 10.1096/fj.202001315rr

Figure Lengend Snippet: FIGURE 9 Application of PTX leads to improve in behavioral measures of spatial vision in rd10 mouse eyes. Photopic optomotor responses from P41 eyes of rd10 with the application of PTX significantly(P < .05)increased both visual acuity (A, spatial frequency) tested at 100% contrast and contrast sensitivity (B, tested at 0.092 cycle/degree) with 1.5-Hz temporal frequency. PBS loaded as vehicle control had no statistic difference to the rd10 untreated group. For all panels, data are presented as mean ± SEM, significance is based on unpaired Student's t test, where *P < .05

Article Snippet: Rd10 mice (RRID:MGI: 3581193; B6.CXB1-Pde6b rd10/J; Jackson laboratory Stock No: 004297) were a kind gift from 15306860, 2020, 11, D ow nloaded from https://faseb.onlinelibrary.w iley.com /doi/10.1096/fj.202001315R R by < Shibboleth> -m em ber@ bcu.ac.uk, W iley O nline L ibrary on [13/05/2024].

Techniques: Control